C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/88 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01) C12N 9/00 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2275455
The invention relates to an ionic conjugate, which is stable in a biological medium, and which is comprised of a particle vector with at least one cationic, nonliquid, hydrophilic nucleus and of polyanionic oligonucleotides. The invention further concerns the pharmaceutical compositions containing these conjugates and the use of a particle vector to carry the oligonucleotides to the cells.
L'invention concerne un conjugué ionique, stable dans un milieu biologique, d'un vecteur particulaire comprenant au moins un noyau hydrophile non liquide cationique et d'oligonucléotides polyanioniques. L'invention concerne aussi les compositions pharmaceutiques contenant ces conjugués et l'utilisation de vecteur particulaire pour délivrer des oligonucléotides dans les cellules.
Betbeder Didier
de Miguel Ignacio
Jarvis Thale
Kravtzoff Roger
Pavco Pamela
Biovector Therapeutics (s.a.)
Gowling Lafleur Henderson Llp
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