Conjugates of a polymer and a protein linked by an oxime...

Details Conjugates of a polymer and a protein linked by an oxime... Conjugates of a polymer and a protein linked by an oxime...

C - Chemistry, Metallurgy

12

N

C12N 11/10 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 14/745 (2006.01) C07K 17/08 (2006.01) C07K 17/10 (2006.01) C12N 9/64 (2006.01) C12N 9/74 (2006.01) C12N 11/08 (2006.01) C07K 14/505 (2006.01)

Patent

CA 2534412

The present invention relates to polymers functionalized by an aminooxy group or a derivative thereof, conjugates, wherein the functionalized polymers are covalently coupled with a protein by an oxime linking group, a process for preparing the functionalized polymers, a process for preparing the conjugates, functionalized polymers as obtainable by the process of the present invention, conjugates as obtainable by the process of the present invention, and pharmaceutical compositions comprising at least one conjugate of the present invention and the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.

L'invention concerne des polymères fonctionnalisés au moyen d'un groupe aminooxy ou un dérivé de ceux-ci, des conjugués dans lesquels les polymères fonctionnalisés sont couplés de manière covalente avec une protéine au moyen d'un groupe de liaison oxime, un procédé de préparation des polymères fonctionnalisés, un procédé de préparation des conjugués, des polymères fonctionnalisés pouvant être obtenus au moyen du procédé de l'invention, des conjugués fonctionnalisés pouvant être obtenus au moyen du procédé de l'invention, des compositions pharmaceutiques comprenant au moins un conjugué de l'invention et l'utilisation desdits conjugués et compositions pour la prophylaxie ou la thérapie du corps humain ou animal.

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