Conjugates of a therapeutic agent and a peptide carrier

Details Conjugates of a therapeutic agent and a peptide carrier Conjugates of a therapeutic agent and a peptide carrier

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2428971

A composition comprising a polypeptide and benzatropine mesylate covalently attached to the polypeptide. Also provided is a method for delivery of benzatropine mesylate to a patient comprising administering to the patient a composition comprising a polypeptide and benzatropine mesylate covalently attached to the polypeptide. Also provided is a method for protecting benzatropine mesylate from degradation comprising covalently attaching it to a polypeptide. Also provided is a method for controlling release of benzatropine mesylate from a composition comprising covalently attaching it to the polypeptide.

L'invention concerne une composition comprenant un polypeptide et du benzatropine mésylate relié par covalence au polypeptide. La présente invention concerne également un procédé d'administration de benzatropine mésylate à un patient, consistant à administrer au patient une composition comprenant un polypeptide et du benzatropine mésylate relié par covalence au polypeptide. En outre, cette invention concerne un procédé permettant de protéger le benzatropine mésylate contre la dégradation, qui consiste à relier le benzatropine mésylate par covalence à un polypeptide. L'invention concerne également un procédé de régulation de la libération de benzatropine mésylate d'une composition, consistant à relier par covalence le benzatropine mésylate au polypeptide.

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