Conjugates of an anti-tnf-alpha antibody

Details Conjugates of an anti-tnf-alpha antibody Conjugates of an anti-tnf-alpha antibody

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 39/44 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2648582

Conjugates of an anti-TNF antibody and one or more nonpeptidic water soluble polymers are provided. Typically, the nonpeptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.

La présente invention concerne des conjugués d'un anticorps anti-TNF et d'un ou de plusieurs polymères non peptidiques hydrosolubles. Généralement, le polymère non peptidique hydrosoluble est du poly(éthylène glycol) ou un dérivé de ce composé. De plus, l'invention porte, entre autres, sur des compositions contenant les conjugués, sur des procédés de fabrication des conjugués, et sur des procédés d'administration de compositions à un patient.

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