A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2657276
The present invention is directed to conjugated compounds comprising a folate, or an analog or derivative thereof, and an aziridinyl epothilone analog, as further described herein, and/or pharmaceutically-acceptable salts and/or solvates thereof, useful in the treatment of cancer or other folate-receptor associated conditions.
La présente invention concerne des composés conjugués comprenant un folate, ou l'un de ses analogues ou dérivés, et un analogue d'aziridinyl-épothilone, comme décrit ci-après, et/ou leurs sels et/ou solvates de qualité pharmaceutique, lesdits composés pouvant être employés dans le traitement du cancer ou d'autres états pathologiques faisant intervenir le récepteur du folate.
Leamon Christopher P.
Lee Francis Y.
Vite Gregory D.
Vlahov Iontcho R.
Bristol-Myers Squibb Company
Endocyte Inc.
Gowling Lafleur Henderson Llp
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