C - Chemistry – Metallurgy – 07 – G
Patent
C - Chemistry, Metallurgy
07
G
C07G 11/00 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) A61K 49/00 (2006.01) C07G 3/00 (2006.01) C07H 17/08 (2006.01)
Patent
CA 2476423
This invention features a compound of the following formula T-(-L-C)m, wherein T is a transportophore (a transport mediating molecule), L is a a non- antibiotic therapeutic agent, and m is l- 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2. Figure 1 depicts comparison of selective uptake of diverse structure types into white blood cells from a complex blood mix.
L'invention concerne un composé représenté par la formule T-(-L-C)¿m,? dans laquelle T représente un transportophore, L représente une liaison ou un liant dont le poids moléculaire peut aller jusqu'à 240 dalton, C est un agent thérapeutique non antibiotique, et m est égal à l, 2, 3, 4, 5, 6, 7, ou 8. Ledit transportophore présente un rapport de sélectivité immunitaire d'au moins 2 tout en étant lié par covalence à l'agent thérapeutique antibiotique via la liaison ou le liant ; le composé présentant un rapport d'immunité sélective d'au moins 2.
Barker Laurence
Beck Albert
Burnet Michael
Busch Maximilian
Droste-Borel Irina
Merckle Gmbh
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sympore Gmbh
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