Conjugates of biologically active proteins having a modified...

Details Conjugates of biologically active proteins having a modified... Conjugates of biologically active proteins having a modified...

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2595695

Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.

L'invention se rapporte à des conjugués de protéine biologiquement active contenant un polypeptide biologiquement actif relié au moyen d'une liaison peptidique à un polypeptide comprenant environ 2 à 50 unités d'un motif de peptide à répétition, le conjugué de protéine biologiquement active présente une demi-vie plasmatique modifiée en comparaison avec la demi-vie intrinsèque du polypeptide ou de la protéine biologiquement active non conjuguée. L'invention porte aussi sur des procédés de fabrication et d'utilisation des protéines conjuguées, ainsi que sur des procédés permettant de déterminer si un conjugué donné présente une demi-vie modifiée par rapport à la demi-vie intrinsèque du polypeptide non conjugué.

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