Conjugates of biotin and deferoxamine for radioimmunoimaging...

Details Conjugates of biotin and deferoxamine for radioimmunoimaging... Conjugates of biotin and deferoxamine for radioimmunoimaging...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07F 5/00 (2006.01) C07F 15/00 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2131382

2131382 9317714 PCTABS00025 The present invention provides compounds which are covalent conjugates of deferoxamine and biotin or derivatives thereof. The subject compounds are capable of binding metal ions and avidin or streptavidin, and accordingly are useful in two-step radioimmunoimaging and radioimmunotherapy. Methods for the synthesis of the deferoxamine-biotin conjugates are also provided by the present invention.

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