C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/22 (2006.01) A61K 31/424 (2006.01) A61P 35/00 (2006.01) C07D 498/18 (2006.01) C07K 14/59 (2006.01) C07K 14/655 (2006.01)
Patent
CA 2662308
The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and anti-bodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
La présente invention concerne des conjugués de disorazoles et leurs dérivés avec des molécules se fixant à des cellules, telles que des peptides, des protéines, des hormones, des protéines sanguines et des anticorps. La présente invention concerne également de nouveaux dérivés de disorazole et des procédés destinés à la fabrication de ces conjuguées et de ces dérivés de disorazole. Ces composés peuvent être utilisés comme médicaments pour le traitement de troubles physiologiques et/ou physiopathologiques chez des mammifères, en particulier pour le traitement de diverses tumeurs.
Guenther Eckhard
Paulini Klaus
Schaefer Olaf
Teifel Michael
Aeterna Zentaris Gmbh
Marks & Clerk
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