C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 31/56 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2338342
The present invention relates to novel compounds comprising a steroid hormone linked to a DNA-interacting molecule that target nucleic acids to the cell nucleus. Further, the invention relates to a method for introducing nucleic acids into the nucleus of cells with the help of such compounds. Pharmaceutical preparations containing such compounds and the use of such compounds for gene therapy are also provided.
L'invention concerne de nouveaux composés renfermant une hormone stéroïde liée à une molécule d'interaction avec l'ADN qui dirige les acides nucléiques vers le noyau cellulaire. L'invention concerne également un procédé d'introduction des acides nucléiques dans le noyau de cellules à l'aide de ces composés. Font aussi l'objet de cette invention les préparations pharmaceutiques renfermant ces composés et leur utilisation en thérapie génique.
Frey Brigitte
Frey Felix
Rusconi Sandro
Wehrli Hans-Ueli
Frey Felix
Rusconi Sandro
Smart & Biggar
LandOfFree
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