Conjugates of glp-1 agonists and uses thereof

Details Conjugates of glp-1 agonists and uses thereof Conjugates of glp-1 agonists and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/22 (2006.01) A61K 38/26 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 14/575 (2006.01) C07K 14/65 (2006.01) C07K 14/81 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2740316

The present invention features a compound having the formula A-X-B, where A is peptide vector capable of enhancing transport of the compound across the blood-brain barrier or into particular cell types, X is a linker, and B is a GLP-1 agonist (e.g., exendin-4 or an exendin-4 analog). The compounds of the invention can be used to treat any disease where increased GLP-1 activity is desired, for example, metabolic diseases, such as obesity and diabetes.

La présente invention porte sur un composé répondant à la formule A-X-B, dans laquelle A représente un vecteur peptidique pouvant augmenter le transport du composé à travers la barrière hémato-encéphalique ou dans des types particuliers de cellules, X représente un groupe de liaison et B représente un agoniste de GLP-1 (par exemple l'exendine-4 ou un analogue de l'exendine-4). Les composés de l'invention peuvent être utilisés pour traiter n'importe quelle maladie pour laquelle une activité accrue de GLP-1 est souhaitée, par exemple des maladies métaboliques, telles que l'obésité et le diabète.

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