Conjugates of hydroxyalkyl starch and a protein, prepared by...

Details Conjugates of hydroxyalkyl starch and a protein, prepared by... Conjugates of hydroxyalkyl starch and a protein, prepared by...

C - Chemistry, Metallurgy

08

B

C08B 31/00 (2006.01) A61K 47/48 (2006.01) C07K 14/00 (2006.01) C08B 31/18 (2006.01)

Patent

CA 2558738

The present invention relates to conjugates of hydroxyalkyl starch, preferably hydroxyethyl starch, and a protein, wherein these conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. The present invention also relates to the method of producing these conjugates and specific uses of the conjugates.

La présente invention a trait à des conjugués d'hydroxyalkyle, de préférence l'amidon d'hydroxyalkyle, et d'une protéine, dans lesquels les conjugués sont formés par une réaction d'amination réductrice entre au moins un groupe aldéhyde ou un groupe céto ou un groupe hémiacétal de l'amidon d'hydroxyalkyle ou un dérivé de l'amidon d'hydroxyalkyle, et au moins un groupe amino de la protéine, de sorte que l'amidon d'hydroxyalkyle ou son dérivé soit en liaison covalente avec le protéine via une liaison azométhine ou une liaison amino. La présente invention a également trait au procédé de production de ces conjugués et à des utilisations spécifiques des conjugués.

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