C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/08 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) C07K 14/65 (2006.01)
Patent
CA 2592006
A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar aminio acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.
L'invention concerne un conjugué constitué d'un facteur de croissance 1 analogue à l'insuline (IGF-I) et au moins un groupe poly(éthylène glycol), se caractérisant en ce que ledit variant IGF-I présente une altération d'acide aminé au niveau de trois positions d'acides aminés 27, 37, 65, 68 de la séquence d'acides aminés d'IGF-I de type sauvage, de sorte qu'au moins un acide aminé est lysine et l'acide aminé 27 est un acide aminé polaire mais non lysine, qui est conjugué par le biais des groupes aminés primaires des lysines et les groupes poly(éthylène glycol) ont un poids moléculaire globale compris entre 20 et 100 kDa. Ce conjugué est utilisé dans le traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer.
Amrein Beat
Foser Stefan
Hesse Friederike
Kuenkele Klaus-Peter
Lang Kurt
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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