Conjugates of neurotensin or neurotensin analogs and uses...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01) C07K 14/81 (2006.01) C07K 17/00 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2745524

The present invention features a compound having the formula A-X-B, where A is peptide vector capable of enhancing transport of the compound across the blood-brain barrier or into particular cell types, X is a linker, and B is a peptide therapeutic selected from the group consisting of neurotensin, a neurotensin analog, or a neurotensin receptor agonist. The compounds of the invention can be used to treat any disease in which increased neurotensin activity is useful and can be used to induce hypothermia or analgesia.

La présente invention concerne un composé de formule A-X-B, où A est un vecteur peptidique pouvant améliorer le transport du composé à travers la barrière sang-cerveau ou dans des types de cellules particuliers, X est un pont et B est un agent thérapeutique peptidique choisi dans le groupe constitué par la neurotensine, un analogue de neurotensine ou un agoniste de récepteur de la neurotensine. Les composés selon l'invention peuvent être employés dans le traitement de toute maladie pouvant être améliorée par une augmentation de l'activité de la neurotensine ou dans l'induction de l'hypothermie ou de l'analgésie.

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