A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 41/00 (2006.01)
Patent
CA 2494214
Conjugates of porphyrins with chemotherapeutic agents are disclosed, as well as methods of making the conjugates and methods of treating patients with the conjugates. Porphyrin compounds, such as mesoporphyrin IX, can be covalently linked to chemotherapeutic compounds, such as doxorubicin. The resulting conjugates display decreased systemic toxicity, while preserving the antineoplastic effects of the chemotherapeutic agent. The conjugates are thus useful in treating cancer and other diseases marked by uncontrolled cell proliferation.
Cette invention concerne des conjugués de porphyrines et d'agents chimiothérapeutiques ainsi que des techniques d'obtention de ces conjugués et des méthodes de traitement de patients à l'aide desdits conjugués. Des composés de porphyrine, tels que la mésoporphyrine IX, peuvent être liés de manière covalente à des composés chimiothérapeutiques tels que la doxorubicine. Les conjugués ainsi obtenus présentent une toxicité systémique réduite sans compromettre pour autant les effets anti-néoplasiques de l'agent chimiothérapeutique. Ces conjugués conviennent donc pour le traitement du cancer et autres maladies caractérisées par une prolifération cellulaire sauvage.
Frydman Benjamin
Kink John A.
Marton Laurence J.
Valasinas Aldonia L.
Borden Ladner Gervais Llp
Cellgate Inc.
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