A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 41/00 (2006.01) A61K 47/48 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2661319
Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
La présente invention concerne des conjugués de photosensibilisants à la porphyrine, à la chlorophylle et à la bactériochlorophylle et de peptides contenant RGD ou de peptidomimétiques RGD qui sont utiles pour la thérapie photodynamique (TPD), notamment la TPD ciblée sur les vaisseaux, de tumeurs et de maladies vasculaires non néoplasiques telles que la dégénérescence maculaire liée à l'âge et pour le diagnostic de tumeurs au moyen de différentes techniques.
Brandis Alexander
Eren Doron
Neimann Karin
Rubinstein Efrat
Salomon Yoram
Borden Ladner Gervais Llp
Yeda Research And Development Co. Ltd
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