A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/08 (2006.01)
Patent
CA 2501684
The present invention relates to improved 99mTc radiometal complex compositions of aza-diaminedioxime ligands, together with radiopharmaceutical preparations containing them, and kits for the preparation of the radiopharmaceuticals. The technetium metal complexation chemistry of aza- diaminedioxime-targeting molecule chelator conjugates is shown to give rise to a multiplicity of technetium species. The present invention provides an improved aza-diaminedioxime conjugate technetium metal complex composition in which the presence of the less desirable technetium species is suppressed.
L'invention se rapporte à des compositions complexes radiométalliques ?99m¿Tc améliorées de ligands aza-diaminedioxime, à des préparations radiopharmaceutiques contenant lesdites compositions, et des trousses de préparation desdites préparations radiopharmaceutiques. La composition chimique de la complexation du métal technétium des conjugués chélateurs à molécule de ciblage aza-diaminedioxime est présentée pour obtenir une multiplicité d'espèces de technétium. L'invention concerne une composition améliorée complexe de métal technétium conjugué à aza-diaminedioxime dans laquelle la présence des espèces de technétium les moins désirables est supprimée.
Barnett David Jonathan
Brauers Georg
Farrar Gillian
Lewis Joanne Sarah
Wadsworth Harry John
Fetherstonhaugh & Co.
Ge Healthcare Limited
LandOfFree
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