Conjugates of the c domain of human gelatinase a and...

Details Conjugates of the c domain of human gelatinase a and... Conjugates of the c domain of human gelatinase a and...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/48 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2475370

A conjugate comprising the C domain of human gelatinase A (PEX domain, PEX) and one to three poly(ethylene glycol) groups), said poly(ethylene glycol) group(s) having an overall molecular weight of from about 10 to 40 kDa and being conjugated via primary amino group(s) of said PEX is useful for the treatment of cancer.

L'invention concerne un conjugué comprenant le domaine C de la gélatinase humaine A (PEX domaine, PEX) et un à trois groupements polyéthylène glycol, lesdits groupements ayant un poids moléculaire global situé entre environ 10 et 40 kDa et étant conjugués par le biais de groupements amino primaires dudit PEX, qui est utile dans le traitement du cancer.

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