Conjugates of vitamin b12 and proteins

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 17/10 (2006.01) A61K 38/18 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) C07K 14/505 (2006.01) C07K 14/535 (2006.01) C07K 14/555 (2006.01)

Patent

CA 2195566

Therapeutically useful proteins are conjugated to vitamin B12 by covalent binding at the primary hydroxyl site of the ribose moiety. The resulting conjugates are biologically active and can be formulated into pharmaceutical compositions suitable for delivery by various routes of administration, preferably oral. Uptake in the gut following oral delivery is further enhanced by the co-administration of purified intrinsic factor.

La présente invention consiste à conjuguer des protéines d'utilité thérapeutique à la vitamine B¿12? par liaison covalente au niveau du site hydroxyle primaire d'un segment ribose. Les conjugués résultants sont biologiquement actifs et peuvent se formuler en compositions pharmaceutiques convenant à l'administration par voies diverses, de préférence par voie orale. La co-administration de facteur intrinsèque purifié améliore la fixation dans l'intestin suivant l'administration par voie orale.

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