Conjugates useful in the treatment of prostate cancer

Details Conjugates useful in the treatment of prostate cancer Conjugates useful in the treatment of prostate cancer

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2268738

Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).

L'invention concerne des conjugués chimiques comprenant des oligopeptides, possédant des séquences d'acides aminées qui sont utilisées de manière protéolytique et de manière sélective par un antigène libre spécifique de la prostate et par des agents cytotoxiques connus. Ces conjugués sont utiles dans le traitement du cancer de la prostate et de l'hypertrophie de la prostate.

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