Conjugates useful in the treatment of prostate cancer

Details Conjugates useful in the treatment of prostate cancer Conjugates useful in the treatment of prostate cancer

A - Human Necessities

61

K

A61K 38/03 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 47/48 (2006.01) C07K 5/00 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 5/117 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2295860

Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by a diamine linker between the oligopeptide and vinblastine. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).

Conjugués chimiques qui comprennent des oligopeptides ayant des séquences d'acides aminés qui sont sélectivement coupées du point de vue protéolytique par l'antigène libre spécifique à la prostate, et des agents cytotoxiques connus. Les conjugués de l'invention se caractérisent par un segment de liaison diaminé entre l'oligopeptide et la vinblastine. Lesdits conjugués sont utiles dans le traitement du cancer prostatique et de l'hypertrophie prostatique bénigne.

Affiliated with

Also associated with

Rating

Conjugates useful in the treatment of prostate cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conjugates useful in the treatment of prostate cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugates useful in the treatment of prostate cancer will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1897198