A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 37/18 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/28 (2006.01) A61K 47/48 (2006.01) C07K 5/107 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2265476
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA), hydrophilic oligopeptide blocking groups and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
La présente invention concerne des conjugués chimiques comprenant des oligopeptides dont les séquences d'acide aminé sont sélectivement coupées de façon protéolytique par un antigène prostate-spécifique libre, des groupes de blocage d'oligopeptides hydrophiles et des agents cytotoxiques connus. Ces conjugués sont utiles dans le traitement du cancer de la prostate et de l'hypertrophie prostatique bénigne.
Feng Dong-Mei
Garsky Victor M.
Jones Raymond E.
Oliff Allen I.
Wai Jenny M.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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