Conjugates with anti-inflammatory activity

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 43/00 (2006.01) A61K 31/58 (2006.01) A61P 29/00 (2006.01) C07D 267/00 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2585711

The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure VIII: L represents the chain of the substructure IX or XIII: Z represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.

Nouveaux composés représentés par la formule (I) dans laquelle M représente une sous-unité de macrolide de la sous-structure VIII: L représente la chaîne de la sous-structure IX ou XIII: Z représente la sous-unité stéroïde ou non stéroïde dérivée de médicaments stéroïdes ou non stéroïdes (NSAID) à activité anti-inflammatoire. Sels pharmaceutiquement acceptables et solvates de ces composés préparés destinés à transformer les intermédiaires pour leur préparation et à améliore l'action thérapeutique et l'utilisation de ceux-ci dans le traitement de maladies et d'états inflammatoires chez les humains et les animaux.

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