Conjunctive analysis of biological marker expression for...

Details Conjunctive analysis of biological marker expression for... Conjunctive analysis of biological marker expression for...

G - Physics

01

N

G01N 33/74 (2006.01) G01N 33/558 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2465971

A diagnostic tool is disclosed for accurately and rapidly diagnosing the condition of an ailing organ. Although applicable to numerous organ and organ systems, this application particularly illustrates the concept of conjunctive marker utilization as it relates to diagnosing and distinguishing congestive heart failure. The invention particularly relates to the conjunctive utilization of cardiac Troponin I (cTn-I) and natriuretic peptide, e.g. ANP, pro-ANP, BNP, pro-BNP and CNP as a retrospective tool for diagnosing the underlying mechanism of heart failure and as a prospective analytical device for monitoring disease progression and efficacy of therapeutic agents.

Cette invention porte sur un outil de diagnostic permettant de diagnostiquer rapidement et avec précision l'état d'un organe défaillant. Bien que l'objet de cette invention puisse être appliqué à de nombreux organes et systèmes d'organes, il illustre toutefois en particulier le concept d'utilisation d'un marqueur conjonctif du fait qu'il concerne le diagnostic et la détection d'une insuffisance cardiaque congestive. Cette invention concerne particulièrement l'utilisation conjonctive de la Troponine 1 cardiaque (cTn-1) et du peptide natriurétique, tel que ANP, pro-ANP, BNP, pro-BNP et CNP comme outil rétrospectif servant au diagnostic du mécanisme sous-jacent de l'insuffisance cardiaque et comme dispositif analytique prospectif servant à surveiller l'évolution d'une maladie et l'efficacité d'agents thérapeutiques.

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