C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2222509
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides CTGF, and including 5'and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
L'invention concerne un nouveau polypeptide, le facteur de croissance des tissus conjonctifs (CTGF), des polynucléotides codant ledit facteur CTGF et comprenant des nucléotides non traduits en 5' et 3', des anticorps réagissant audit facteur et des moyens de production de CTGF. Elle porte également sur des méthodes diagnostiques et thérapeutiques d'utilisation du facteur CTGF, ainsi que sur une technique pour identifier les compositions modifiant l'expression du polynucléotide de CTGF. Elle se rapporte enfin à un nouvel élément réagissant à TGF-.beta. en aval du polynucléotide codant le gène structural de CTGF.
Bradham Douglass M.
Grotendorst Gary R.
Mbm Intellectual Property Law Llp
University Of South Florida
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