C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/39 (2006.01) A61P 35/00 (2006.01) C07K 14/475 (2006.01) C07K 14/49 (2006.01) C07K 14/50 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2412124
The present invention relates to a human CTGH-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for stimulating angiogenesis enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
La présente invention concerne un polypeptide CTGH-2 humain et l'ADN (ARN) codant ce polypeptide, une méthode de production d'un tel polypeptide au moyen de techniques de recombinaison, ainsi que des anticorps et des antagonistes/des inhibiteurs de ce polypeptide. Cette invention a également trait à des méthodes d'utilisation du polypeptide à des fins thérapeutiques pour stimuler l'angiogenèse, améliorer la réparation de tissus conjonctifs et de soutien, promouvoir l'attache, la fixation et la stabilisation des implants, et améliorer la guérison des blessures. Ladite invention concerne aussi des dosages diagnostiques permettant d'identifier des mutations dans une séquence d'acide nucléique codant un polypeptide susmentionné et de détecter des niveaux modifiés dudit polypeptide.
Adams Mark D.
Calenda Valerie
Fataccioli Virginie
Li Haodong
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
Transgene S.a.
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