Connective tissue growth factor homologs

Details Connective tissue growth factor homologs Connective tissue growth factor homologs

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2321176

This present invention is directed to polypeptide and polynucleotide molecules that encode a connective tissue growth factor homolog polypeptide. The human polypeptides have been designated zCTGF4 and the mouse orthologs have been designated zCTGF2. The invention also includes antibodies, expression vectors, host cells expressing zCTGF4 and variants. Also included are methods for producing the polypeptides and using the polynucleotides and the polypeptides.

L'invention concerne des molécules de polypeptides et de polynucléotides codant un polypeptide homologue du facteur de croissance pour le tissu conjonctif. Les polypeptides humains ont été désignés zCTGF4, et les orthologues chez les souris ont été désignés zCTGF2. L'invention concerne également des anticorps, des vecteurs d'expression, des cellules hôtes exprimant le zCTGF4 et des variantes. L'invention concerne en outre des procédés relatifs à la production des polypeptides et à l'utilisation des polynucléotides et des polypeptides considérés.

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