Connective tissue stimulating peptides

Details Connective tissue stimulating peptides Connective tissue stimulating peptides

C - Chemistry, Metallurgy

07

K

C07K 14/78 (2006.01) A61K 38/00 (2006.01) A61K 38/39 (2006.01) A61P 19/00 (2006.01) C07K 19/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2489009

Novel peptides are described which comprise an amino acid motif selected from the group consisting of "PG", "GP", "PI" and "IG" and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein "P" in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue.The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.

L'invention concerne de nouveaux peptides comprenant un motif d'acide aminé sélectionné dans le groupe constitué par PG, GP, PI et IG et jusqu'à 10 acides aminés en amont et/ou en aval du motif d'acide aminé dans lequel P représente proline ou hydroxyproline. Le peptide stimule le développement, la conservation et la réparation osseuse, cartilagineuse et de tissulaire conjonctive associée. L'invention concerne également des compositions pharmaceutiques produites à partir desdits peptides ainsi que des utilisations thérapeutiques et prophylactiques de ces peptides.

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