C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2248710
A new peptide, k-conotoxin PVIIA, is disclosed. This peptide is found naturally in the cone snail Conus purpurascens and has the amino acid sequence Cys-Arg-Ile-Xaa-Asn-Gln-Lys-Cys-Phe-Gln-His-Leu-Asp- Asp-Cys-Cys-Ser-Arg-Lys-Cys-Asn-Arg-Phe-Asn-Lys- Cys-Val (SEQ ID NO: 1) where Xaa represents 4-trans-hydroxyproline, hydroxyproline or proline. This peptide together with a previously disclosed peptide, 6-conotoxin PVIA, act synergistically to rapidly immobilize fish which are injected with the two peptides. Injection of r.-conotoxin PVIIA alone results in different symptoms with an injected fish becoming hyperactive and then contracting and suddenly extending all major fins. This "fin-popping" occurs repeatedly resulting in a series of jerky movements, but injection of only k-conotoxin PVIIA does not immobilize or kill the fish.
Grilley Michelle M.
Olivera Baldomero M.
Shon Ki-Joon
Terlau Heinrich
Gowling Lafleur Henderson Llp
Max-Planck Gesellschaft Zur Foerderung Der Wissenschaften E.v.
Max-Planck-Institut Fur Experimentelle Medizin
University Of Utah Research Foundation
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