Consensus/ancestral immunogens

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/21 (2006.01) C07H 21/04 (2006.01) C12N 5/02 (2006.01) C12N 15/74 (2006.01)

Patent

CA 2539325

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

De manière générale, la présente invention concerne un immunogène et, plus particulièrement, un immunogène destiné à induire des anticorps neutralisant un large spectre d'isolats primaires du VIH et/ou un immunogène induisant une réponse immunitaire des lymphocytes T. L'invention concerne également une méthode destinée à induire des anticorps dirigés contre le VIH et/ou une méthode destinée à induire une réponse immunitaire des lymphocytes T au moyen de cet immunogène. Elle se rapporte en outre à des séquences d'acides nucléiques codant pour les immunogènes susmentionnés.

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