Conserved hbv and hcv sequences useful for gene silencing

Details Conserved hbv and hcv sequences useful for gene silencing Conserved hbv and hcv sequences useful for gene silencing

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/713 (2006.01) A61P 31/20 (2006.01) C07H 21/02 (2006.01) C12N 5/10 (2006.01) C12N 15/36 (2006.01) C12N 15/85 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2592099

Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans.

L'invention concerne des séquences consensuelles conservées à partir de souches du virus de l'hépatite B et de l'hépatite C connues, qui sont utilisées pour inhiber l'expression de ces virus dans des cellules mammaliennes. Ces séquences servent au silençage des gènes de VHB et VHC, d'où leur utilité thérapeutique contre les infections virales par le VHB et le VHC chez les humains.

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