Conserved motif of hepatitis c virus e2/ns1 region

Details Conserved motif of hepatitis c virus e2/ns1 region Conserved motif of hepatitis c virus e2/ns1 region

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) C07K 7/06 (2006.01) C07K 14/18 (2006.01) G01N 33/576 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2162557

The hypervariable region (E2HV) of the putative hepatitis C virus (HCV) glycoprotein F2/NS1, between about amino acid 384 to about amino acid 414, is a rapidly evolving region of HCV, and is likely to be under positive immune selection. A newly discovered motif within this hypervariable region is immunogenic and conserved with respect to the character of the amino acids. In many isolates, this motif falls between amino acids 401 to 406 or 407. The discovery of this motif allows for additional materials and methods to treat and diagnose HCV.

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