Conserved t-cell receptor sequences

Details Conserved t-cell receptor sequences Conserved t-cell receptor sequences

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 7/04 (2006.01) C07K 14/725 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188182

Four unique transcripts have been isolated from the .beta. chain of the T-cell receptor in T-cells in the synovial tissue of a patient with rheumatoid arthritis. Two of these transcripts were isolated from fresh synovial tissue and two were isolated from a T-cell line derived from the synovial tissue The sequences of the four transcripts are highly homologous, with a conserved amino acid sequence of IGO N in the highly diverse V-D junction. The .alpha. chain and the antigenic specificity of the T-cell line derived transcripts has also been characterized.

Quatre transcriptions uniques ayant été isolées à partir de la chaîne .beta. du récepteur de lymphocyte T dans les lymphocytes T du tissu synovial d'un patient atteint de polyarthrite rhumatoïde, à raison de deux transcriptions isolées à partir de tissus synoviaux frais, et de deux transcriptions isolées à partir d'une lignée de lymphocytes T dérivée du tissu synovial. Les quatre séquences de transcriptions sont éminemment homologues, et présentent une séquence d'acides aminés IGQ_N conservée aux jonctions V-D hautement diversifiées. La chaîne .alpha. et la spécificité antigénique des transcriptions dérivées de la lignée de lymphocytes T ont également été caractérisées.

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