Constant release rate solid oral dosage formulations of...

Details Constant release rate solid oral dosage formulations of... Constant release rate solid oral dosage formulations of...

A - Human Necessities

61

K

167/166

A61K 47/00 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 31/275 (2006.01)

Patent

CA 1201064

ABSTRACT A constant order release rate solid oral dosage formulation of a drug having a pka 7-10 and a water solubility of from 15-100g/ml water, said formulation comprising: a therapeutically effective amount of a said drug; from about 0.5 to 6.0 weight percent of an acid- retardant or hydrophobic cellulose derivative; from about 2.5 to 35 weight percent of a hydrogenated vegetable oil: from about 1 to 20 weight percent of an acrylic acid polymer; from about 0.5 to 4.0 weight percent of fumed silicon dioxide and from about 0.4 to 300 percent of a lubricant.

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