Constrained cyano compounds

Details Constrained cyano compounds Constrained cyano compounds

A - Human Necessities

61

K

A61K 31/40 (2006.01) C07D 487/00 (2006.01)

Patent

CA 2573848

Certain constrained cyano compounds are useful as inhibitors of post- proline/alanine cleaving amino-dipeptidases. Accordingly, these compounds can be employed, , alone or with another therapeutic agent, to treat diabetes (especially, Type II diabetes), hyperglycemia, Syndrome X, diabetic complications, hyperinsulinemia, obesity, atherosclerosis and related diseases, as well as various immunomodulatory diseases and chronic inflammatory bowel disease.

Certains composés cyano contraints sont utiles en tant qu'inhibiteurs d'amino-dipeptidases coupant post-proline/alanine. En conséquence, ces composés peuvent être utilisés, seuls ou avec un autre agent thérapeutique, pour traiter le diabète (en particulier, le diabète de type II), l'hyperglycémie, le syndrome X, les complications diabétiques, l'hyperinsulinémie, l'obésité, l'athérosclérose et les maladies associées, ainsi que différentes maladies immunomodulatoires et l'affection abdominale inflammatoire chronique.

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