Constrained helical peptides and methods of making same

Details Constrained helical peptides and methods of making same Constrained helical peptides and methods of making same

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01) A61K 39/21 (2006.01) C07K 16/10 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2270869

Provided are cyclized peptides with a constrained region(s) having an .alpha.- helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.

L'invention porte sur des peptides cyclisés possédant une (des) région(s) contrainte(s) à structure hélicoïdale .alpha.. L'invention porte également sur des peptides à structure hélicoïdale contrainte possédant des séquences d'acides aminés issues de la protéine gp41 du VIH, sur leur utilisation dans la préparation d'anticorps qui préviennent la fusion membranaire virale, ainsi que sur des procédés de fabrication de ces peptides cyclisés.

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