Constrained hiv envelope-based immunogen that simultaneously...

Details Constrained hiv envelope-based immunogen that simultaneously... Constrained hiv envelope-based immunogen that simultaneously...

A - Human Necessities

61

K

A61K 39/21 (2006.01) A61K 39/12 (2006.01) C07K 1/00 (2006.01) C07K 14/16 (2006.01) C07K 14/705 (2006.01) C07K 16/10 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) A61K 39/385 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2656741

The present invention relates to a soluble binding complex comprising a soluble gp120 trimer, in which only two gp120 protomers have CD4 binding sites occupied by interconnecting CD4 mimetic moieties, thereby allowing for the exposure of CD4-induced epitopes on the mimetic-bound protomers and an unoccupied CD4 binding site on the third gp120 protomer.

Complexe de liaison soluble comprenant un trimère gp120 soluble, dans lequel seulement deux protomères gp120 ont des sites de liaison CD4 occupés par des fractions mimétiques CD4 d'interconnexion, ce qui permet d'exposer des épitopes à induction CD4 sur les protomères à liaison mimétique et un site de liaison CD4 non occupé sur le troisième protomère gp120.

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