C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) A61K 39/00 (2006.01) A61P 7/04 (2006.01) C12N 9/64 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2519258
It is intended to provide an epitope recognized by an antibody (hereinafter referred to as anti-ADAMTS-13 antibody in some cases) against an enzyme (hereinafter referred to as ADAMTS-13 in some cases) specifically cleaving von Willebrand factor (hereinafter referred to as vWF in some cases), and a polypeptide containing this epitope domain. A polypeptide located at from the 449- to 687-positions in the amino acid sequences constituting ADAMTS-13 which is recognized by the anti-ADAMTS-13 antibody or a peptide fragment originating in this polypeptide.
L'invention concerne l'obtention d'un épitope reconnu par un anticorps (ci-après dénommé anticorps anti-ADAMTS-13 dans certains cas) contre une enzyme (ci-après dénommée ADAMTS-13 dans certains cas) clivant spécifiquement le facteur de Von Willebrand (ci-après dénommé vWF dans certains cas) et un polypeptide contenant ce domaine d'épitope. L'invention concerne également un polypeptide situé au niveau des positions 449 à 687 dans les séquences d'acides aminés constituant ADAMTS-13 lequel est reconnu par l'anticorps anti-ADAMTS-13 ou un fragment peptidique issu de ce polypeptide.
Fujimura Yoshihiro
Matsumoto Masanori
Nakagaki Tomohiro
Soejima Kenji
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Smart & Biggar
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