Construction of new variants of dextransucrase dsr-s by...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12P 19/04 (2006.01) C12P 19/18 (2006.01)

Patent

CA 2639150

The present invention relates to a recombinant process for the production of truncated and/or mutated dextransucrases while conserving their enzymatic activity and/or their specificity in the synthesis of the .alpha.-1 ,6 bonds. More precisely, the present invention relates to nucleic acid sequences of truncated and/or mutated dextransucrases, vectors containing said nucleic acid sequences and host cells transformed by sequences encoding truncated and/or mutated dextransucrases. In a further aspect, the invention concerns a method for producing, in a recombinant manner, truncated and/or mutated dextransucrases which conserve their enzymatic activity and/or which conserve their specificity in the synthsis of .alpha.-1 ,6 bonds and however can produce, from saccharose, dextrans with high molar mass and with modified rheological properties, compared with the properties of dextran obtained with the native enzyme in the same conditions and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and IMO of the invention can be used namely as texturing agents or as prebiotics.

L'invention concerne un processus de recombinaison destiné à la production de dextransucrases tronquées et/ou mutées tout en conservant leur activité enzymatique et/ou leur spécificité dans la synthèse de liaisons .alpha.-1 ,6. Cette invention concerne plus particulièrement des séquences d'acides nucléiques de dextransucrases tronquées et/ou mutées, des vecteurs contenant ces séquences d'acides nucléiques et des cellules hôtes transformées par les séquences codant les dextransucrases tronquées et/ou mutées. Dans un autre de ses aspects, l'invention concerne un procédé destiné à produire, de manière recombinante, des dextransucrases tronquées et/ou mutées qui conservent leur activité enzymatique et/ou leur spécificité dans la synthèse de liaisons .alpha.-1 ,6 et qui permettent toutefois de produire, à partir de saccharose, des dextrans à masse moléculaire élevée et propriétés rhéologiques modifiées, par rapport aux propriétés du dextran obtenu à partir de l'enzyme native dans les mêmes conditions ainsi que des isomalto-oligosaccharides (IMO) à masse molaire contrôlée et des dextrans. Les dextrans et les IMO de l'invention peuvent notamment être utilisés en tant qu'agents texturants ou en tant que prébiotiques.

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