Constructs and libraries comprising antibody surrogate light...

Details Constructs and libraries comprising antibody surrogate light... Constructs and libraries comprising antibody surrogate light...

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2680237

The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.

Cette invention se rapporte à des constructions et des bibliothèques comprenant des séquences de chaînes légères de substitution d'anticorps. L'invention concerne en particulier des constructions comprenant des séquences VpreB, éventuellement couplées avec un autre polypeptide, par exemple des séquences de domaines variables de chaînes légères d'anticorps ; l'invention concerne également des bibliothèques contenant lesdites constructions.

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