Constructs for delivery of therapeutic agents to neuronal cells

Details Constructs for delivery of therapeutic agents to neuronal cells Constructs for delivery of therapeutic agents to neuronal cells

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/33 (2006.01) C07K 14/34 (2006.01) C07K 19/00 (2006.01) C12N 9/02 (2006.01) C12N 9/52 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2392202

A non-toxic polypeptide, for delivery of a therapeutic agent to a neuronal cell, comprises a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the translocation domain is not a HN domain of a clostridial toxin and is not a fragment or derivative of a HN domain of a clostridial toxin.

L'invention concerne un polypeptide non toxique servant à la diffusion d'un agent thérapeutique dans une cellule neuronale. Le polypeptide comprend un domaine de liaison qui se lie à la cellule neuronale, et un domaine de translocation qui diffuse l'agent thérapeutique à l'intérieur de la cellule neuronale. Le domaine de translocation n'est ni un domaine H¿N? d'une toxine clostridiale, ni un fragment ou un dérivé d'un domaine H¿N? d'une toxine clostridiale.

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