Contact drug delivery system

C - Chemistry – Metallurgy – 08 – F

Patent

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Details

C08F 118/00 (2006.01) A61K 31/74 (2006.01)

Patent

CA 2597219

A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio- template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having coamplexing sites, and cross- linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a contact lens for delivering a drug through contact with an eye.

L'invention concerne un système de distribution de médicaments. Ledit système de distribution comprend un hydrogel polymère récognitif via lequel un médicament est distribué par contact avec un tissu biologique. L'hydrogel polymère récognitif est formé à l'aide d'un échantillon biologique qui est un médicament ou est structurellement similaire à ce médicament, de monomères fonctionnalisés, possédant, de préférence, des sites complexants et de monomères de réticulation, qui sont copolymérisés à l'aide d'un amorceur approprié. Les sites complexants de l'hydrogel polymère récognitif ainsi formé miment, de préférence, des sites récepteurs de tissu biologique, la reconnaissance biologique ou un mécanisme d'action biologique. Dans ce mode de réalisation, le système est une lentille de contact destinée à distribuer un médicament par contact avec un oeil.

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