Container closure delivery system

A - Human Necessities – 61 – M

Patent

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Details

A61M 5/315 (2006.01) A61J 1/14 (2006.01) B65B 3/04 (2006.01) B65D 47/00 (2006.01) B65D 83/76 (2006.01)

Patent

CA 2679431

An improved container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.

L'invention concerne un meilleur système de délivrance de fermeture de contenant qui convient pour des produits pharmaceutiques en poudre injectables lyophilisés. Le système comprend des formulations de poudre stables au stockage et une conception d'ensemble fermeture de contenant dans lequel la formulation peut être versée et lyophilisée avec un équipement de finition de remplissage standard, et les formulations et les procédés de lyophilisation sont optimisés pour produire une poudre qui se dissout aisément lors d'un contact avec un diluant, facilitant de ce fait l'injection directe du produit lyophilisé sans besoin d'une étape de reconstitution/de mélange/d'amorçage distincte.

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