Continuous process for the production of optically pure...

Details Continuous process for the production of optically pure... Continuous process for the production of optically pure...

C - Chemistry, Metallurgy

07

D

C07D 307/32 (2006.01) C07D 307/33 (2006.01)

Patent

CA 2416707

Disclosed is a process for the production of optically pure (S)-beta-hydroxy- gamma-butyrolactone through the hydrogenation of substituted carboxylic acid derivatives. A solution containing 1 to 50 % by weight of a substituted carboxylic acid derivative is fed at a WHSV of 0.1 to 10 h-1, to a fixed bed reactor which is filled with a catalyst and maintained at a reaction temperature of 50 to 550 ~C under a halogen partial pressure of 15 to 5,500 psig. The catalyst is composed of a noble metal as a catalytically effective ingredient which is impregnated in an inorganic oxide as a support. The molar ratio of the hydrogen to the substituted carboxylic acid derivative is maintained at a molar ratio of 1:1 to 10:1. The process can produce optically pure (S)-beta-hydroxy-gamma-butyrolactone with higher purities at higher yields than can conventional techniques. In addition to being relatively simple and environmentally friendly, the process is so economically favorable as to apply to industrial production.

Procédé de production de (S)-.beta.-hydroxy-.gamma.-butyrolactone optiquement pure par hydrogénation de dérivés d'acide carboxylique substitués. Une solution contenant 1 à 50 % en poids d'un dérivé d'acide carboxylique substitué est introduit à un VVH de 0,1 à 10 h?-1¿, dans un réacteur à lit fixe rempli d'un catalyseur et maintenu à une température de réaction de 50 à 550 ·C sous une pression partielle d'halogène de 15 à 5,500 psig. Le catalyseur est composé d'un métal noble, en tant qu'ingrédient catalytiquement actif, imprégné dans un support sous forme d'oxyde inorganique. Le rapport molaire de l'hydrogène au dérivé d'acide carboxylique substitué est maintenu entre 1/1 et 10/1. Ledit procédé permet d'obtenir une (S)-bêta-hydroxy-gamma-butyrolactone d'une plus grande pureté et à un rendement plus élevé que les techniques classiques. Outre qu'il est relativement simple et sans danger pour l'environnement, ledit procédé est écomiquement si adapté qu'il peut être appliqué à la production industrielle.

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