Continuous release pharmaceutical compositions

Details Continuous release pharmaceutical compositions Continuous release pharmaceutical compositions

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/20 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) C07K 14/535 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2047540

A B S T R A C T CONTINUOUS RELEASE PHARMACEUTICAL COMPOSITIONS Pharmaceutical compositions for continuous release of a physiologically active substance in which the physiologically active substance comprises a polypeptide covalently conjugated to a water soluble polymer show particularly desirable release characteristics. Polypeptides for use in the pharmaceutical compositions include G-CSF and solution stable derivatives thereof, human calcitonin and interleukin-2. The material of the composition may be a polylactide or biodegradable hydrogel derived from an amphipathic block copolymer. The compositions enable a therapeutically effective polypeptide to be continuously released over a prolonged period of time following a single administration of the pharmaceutical composition to a patient.

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