Continuous sonication method for preparing protein...

Details Continuous sonication method for preparing protein... Continuous sonication method for preparing protein...

A - Human Necessities

61

K

167/46, 204/91

A61K 49/00 (2006.01) A61K 9/50 (2006.01) A61K 49/22 (2006.01)

Patent

CA 1337286

An ultrasonic imaging agent is produced by a continuous sonication processing of an aqueous solution of heat-denaturable biocompatible protein. The solution is carefully preheated to a temperature of incipient protein denaturation without forming insolubilized pro- tein. A gaseous fluid, preferably air, is added to the solution. In the sonication, the air-containing solu- tion is foamed, increasing the formation and concentra- tion of microbubbles, and the solution is further heated to insolubilize a portion of the protein, thereby encap- sulating the microbubbles and forming particulate micro- spheres.

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