Contortrostatin (cn) and methods for its use in preventing...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 14/00 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2343716

The amino acid sequence of native contortrostatin was used in a cloning strategy to obtain full-length cDNA and deduced amino acid sequnces for a contortrostatin precursor. The precursor includes pro-protein, metalloproteinase, and disintegrin (contortrostatin) regions of the multidomain protein. The sequences can be used to produce recombinant DNA molecules which code on expression for contortrostatin proteins, including biologically active variants and fragments. When formulated as a pharmaceutically acceptable composition, the proteins can be used to treat patients by inhibiting disease processes associated with an integrin binding to an integrin receptor.

On a utilisé la séquence d'acides aminés de la contortrostatine endogène dans une stratégie de clonage pour obtenir de l'ADNc entier et des séquences d'acides aminés déduites correspondant à un précurseur de la contortrostatine. Le précurseur comprend les parties suivantes de la protéine multidomaine: pro-protéine, métalloprotéinase et disintégrine (contortrostatine). On peut utiliser les séquences pour produire des molécules d'ADN de recombinaison assurant un codage à l'expression pour les protéines de contortrostatine, y compris les variants et les fragments biologiquement actifs correspondants. Lorsqu'elles sont formulées dans une composition pharmaceutiquement acceptable, les protéines peuvent être utilisées pour traiter les patients par inhibition des processus de maladie associés à la liaison entre l'intégrine et un récepteur de l'intégrine.

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