Contortrostatin (cn) and methods for its use in preventing...

Details Contortrostatin (cn) and methods for its use in preventing... Contortrostatin (cn) and methods for its use in preventing...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2393463

Contortrostatin, a homodimeric disintegrin, modulates the adhesion, motility, and invasiveness of integrin expressing tumor cells. When formulated as a pharmaceutically acceptable composition, the proteins can be used to treat patients by inhibiting or disrupting disease processes associated with an integrin binding to an .alpha..nu..beta.3 or .alpha..nu..beta.5 integrin.

Selon l'invention, la contortrostatine, une disint~grine homodim~rique, module l'adh~sion, la motilit~, et le pouvoir envahissant de cellules tumorales exprimant une int~grine. Lorsqu'elles sont formul~es en tant que composition pharmaceutiquement acceptable, les prot~ines peuvent Útre utilis~es pour le traitement de patients par inhibition ou interruption de processus pathologiques associ~s ~ une int~grine se liant ~ une .alpha..nu..beta.3 ou .alpha..nu..beta.5 int~grine.

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