Contraception using competitive progesterone antagonists,...

Details Contraception using competitive progesterone antagonists,... Contraception using competitive progesterone antagonists,...

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01) A61K 31/00 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2135608

Competitive arogesterone antagonists, including two novel steroids, viz., 11.beta.,19-[4-(cyanophenyl)-o-phenylene]- 17.beta.-hydroxy-17.alpha.-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one and 11.beta.,19-[4-(3-pyridinyl)-o-phenylene]-17.beta.-hydroxy-17.alpha. -(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one, inhibit formation of endometrial glands at below their ovulation inhibiting dose and the abortive dose, and thus achieve oral contraception in females without adversely affecting the menstrual cycle and without risk of.aborting a previous implanted fertilized egg or a fetus.

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