C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01)
Patent
CA 2350917
The invention provides an antibody contraceptive vaccine comprising an antibody that has at least one CDR containing a portion of an antigen of a cell or protein associated with reproductive function and which antibody has an enhanced ability to elicit an anti-idiotype response, for example, by substituting one or more variable region cysteine residues that form intrachain disulfide bonds with an amino acid residue that does not have a sulfhydryl group, such that the intrachain disulfide bond does not form. The invention further provides methods of contraception using the antibody contraceptive vaccines of the invention.
L'invention concerne un vaccin contraceptif comprenant un anticorps, lequel possède au moins une région CDR contenant une portion d'un antigène d'une cellule ou protéine associée à la fonction reproductrice et a une capacité accrue de produire une réponse anti-idiotype, par exemple, par substitution d'au moins un reste cystéine à région variablelequel forme des liaisons disulfure intracaténaires- par un reste d'acide aminé ne possédant pas de groupe sulfhydryle, de façon qu'il ne se forme pas de liaison disulfure intracaténaire. L'invention concerne encore des méthodes de contraception consistant à utiliser ces vaccins contraceptifs comprenant un anticorps.
Burch Ronald M.
Sackler David A.
Euro-Celtique S.a.
Osler Hoskin & Harcourt Llp
LandOfFree
Contraceptive antibody vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Contraceptive antibody vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Contraceptive antibody vaccines will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1406364